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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Fluorescent glucose biosensor ： ウィキペディア英語版 Fluorescent glucose biosensor Fluorescent glucose biosensors are devices that measure the concentration of glucose in diabetic patients by means of sensitive protein that relays the concentration by means of fluorescence, an alternative to amperometric sension of glucose. No device has yet entered the medical market,〔No fluorescent biosensor has yet entered the medical market, however, in the market for research tools several fluorescent biosensors are present, such as a (kit ) using (fischeri )〕 but, due to the prevalence of diabetes, it is the prime drive in the construction of fluorescent biosensors. ==Application== (詳細はConcanavalin A.〔〔Ballerstadt, R. and J.S. Schultz, A fluorescence affinity hollow fiber sensor for continuous transdermal glucose monitoring. Anal Chem, 2000. 72(17): p. 4185-92.〕〔Sato, K. and J. Anzai, Fluorometric determination of sugars using fluorescein-labeled concanavalin A-glycogen conjugates. Anal Bioanal Chem, 2006. 384(6): p. 1297-301.〕〔Liao, K.C., et al., Percutaneous fiber-optic sensor for chronic glucose monitoring in vivo. Biosens Bioelectron, 2008. 23(10): p. 1458-65.〕〔Ballerstadt, R., et al., In vivo performance evaluation of a transdermal near- infrared fluorescence resonance energy transfer affinity sensor for continuous glucose monitoring. Diabetes Technol Ther, 2006. 8(3): p. 296-311.〕 Over the years, using a combination of rational design and screening approaches, many possible combinations of fluorescent sensor for glucose have been studied with varying degrees of success: In most approaches, the glucose concentration is translated into a change in fluorescence either by using a pair〔〔〔〔〔Chinnayelka, S. and M.J. McShane, RET nanobiosensors using affinity of an apo-enzyme toward its substrate. Conf Proc IEEE Eng Med Biol Soc, 2004. 4: p. 2599-602.〕〔McCartney, L.J., et al., Near-infrared fluorescence lifetime assay for serum glucose-based on allophycocyanin-labeled concanavalin A. Anal Biochem, 2001. 292(2): p. 216-21.〕〔Hanashi, T., et al., BioCapacitor-A novel category of biosensor. Biosens Bioelectron, 2009.〕〔Sakaguchi-Mikami, A., et al., Engineering of ligand specificity of periplasmic binding protein for glucose sensing. Biotechnol Lett, 2008. 30(8): p. 1453-60.〕 or by using environment sensitive (solvatochromic) dyes〔Khan, F., L. Gnudi, and J.C. Pickup, Fluorescence-based sensing of glucose using engineered glucose/galactose-binding protein: a comparison of fluorescence resonance energy transfer and environmentally sensitive dye labelling strategies. Biochem Biophys Res Commun, 2008. 365(1): p. 102-6.〕〔Brown, J.Q., et al., Enzymatic fluorescent microsphere glucose sensors:evaluation of response under dynamic conditions. Diabetes Technol Ther, 2006. 8(3): p. 288-95.〕〔Salins, L.L., et al., A novel reagentless sensing system for measuring glucose-based on the galactose/glucose-binding protein. Anal Biochem, 2001. 294(1): p. 19-26.〕 in a variety of combinations, the fluorescent small molecule,〔〔 protein〔〔Teasley Hamorsky, K., et al., A bioluminescent molecular switch for glucose. Angew Chem Int Ed Engl, 2008. 47(20): p. 3718-21.〕〔Ye, K. and J.S. Schultz, Genetic engineering of an allosterically based glucose indicator protein for continuous glucose monitoring by fluorescence resonance energy transfer. Anal Chem, 2003. 75(14): p. 3451-9.〕 or quantum dot〔〔Tang, B., et al., A new nanobiosensor for glucose with high sensitivity and selectivity in serum-based on fluorescence resonance Energy transfer ( ) between CdTe quantum dots and Au nanoparticles. Chemistry, 2008. 14(12): p. 3637-44.〕 have been used in conjunction with a glucose binding moiety either a boronic acid functionalized fluorophore〔〔Uwira, N., N. Opitz, and D.W. Lubbers, INFLUENCE OF ENZYME CONCENTRATION AND THICKNESS OF THE ENZYME LAYER ON THE CALIBRATION CURVE OF THE CONTINUOUSLY MEASURING GLUCOSE OPTODE. Advances in Experimental Medicine and Biology, 1984. 169: p. 913-921.〕 or a protein, such as glucose oxidase,〔〔Schultz, J.S., S. Mansouri, and I.J. Goldstein, Affinity sensor: a new technique for developing implantable sensors for glucose and other metabolites. Diabetes Care, 1982. 5(3): p. 245-53.〕 concanavalin A,〔〔〔〔 glucose/galactose-binding protein,〔〔〔 glucose dehydrogenase〔 and glucokinase.〔〔Schaffar, B.P.H. and O.S. Wolfbeis, A FAST RESPONDING FIBER OPTIC GLUCOSE BIOSENSOR BASED ON AN OXYGEN OPTRODE. Biosensors & Bioelectronics, 1990. 5(2): p. 137-148〕 In general, the change seen with competition assays is small (see below). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Fluorescent glucose biosensor」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.